Rosanna Arquette on what it was like to play a villain on the show:

"You know, it was challenging. There was this one moment where I had to strangle this man. And I found myself getting really nauseous. Every time I would do [it], I kind of felt sick to my stomach. And I said, this feeling that comes - it’s because that is wrong, you know. I mean, it’s amazing the people who actually really do these things, how they can get to that place. But it was hard. I don’t know if I would want to do it a lot. It was interesting to be in somebody’s skin that could do that. But it was interesting to play, for me, something that I’ve never done before because I haven’t ever done that."

Rosanna and Patricia on what it was like for Rosanna to play a "Cougar", too:

ROSANNA: It was fun. I was discovering the character as I went along, which was a really interesting way to working, and they do that a lot on that show. So, you know, I’ve never been one to go out really with younger men but it did spark and idea in me. Like, "Wow, this is not so bad."

PATRICIA: I thought, because I know my sister so well, it’s a testament to what a great actress she is. I mean, physically she is a very beautiful woman but she’s a very natural woman in real life. I knew she would look gorgeous and she looks gorgeous. But to see her as this sort of carnivorous mercenary, kind of dangerous person, it was so different for me to see her in that. So part of the reason I was just enjoying it so much was enjoying my sister’s incredible talent.

ROSANNA: Aww.

Patricia Arquette on the most interesting aspects on working with her siblings on the show:

"You know, I think the really interesting thing about us as artists together - when I did work with Rich on the show or David or Rosanna - is the collaborative exchange of ideas... All of us are open to each other and all of us respect each other’s mind as artists. And so it’s not uncomfortable on the way it might be for some people."

Patricia and her feelings on the current state and season of Medium and whether there will be another season:

"I feel like we’ve really had a lot of good luck with having Angelica Huston come in and have Rosanna come in and now Kelly Preston is going to come in so we’ve been really lucky in that way; having a lot of great guest stars and that’s been really exciting. It’s always hard for me to tell honestly. Usually I watch the whole season at the end; I don’t actually watch it every week because we’re usually working when it’s on. And then the idea of making my children watch [and] wait around while I’m watching myself is too strange of an idea for me. So I’m not sure. It’s sort of like life, when you’re in it, it’s hard to see outside of it. And I don’t know if there’ll be a next season. I know we do have very devoted fans and that we’re grateful for that."

Patricia and Rosanna on what it was like to get back to work after the writers' strike:

PATRICIA: I was glad everyone got to get back to work. I mean, I felt like it was an inevitable strike and that they really had to come to some kind of an agreement together and I was glad they eventually did. But it felt like it took a lot longer than it needed to.

ROSANNA: It was debilitating for a lot of people. I mean, it was a really hard strike; a lot of people got truly affected by it. And hopefully the actors will come to an agreement and not have to strike. But I’m glad people are back at work. I sure am.

Patricia and Rosanna on how their relationship evolved when they were young and what Patricia thought of her older sister when she was growing up:

PATRICIA: Well, I think Rosanna did fall into that sort of trap of having to help with so many siblings because there was four of us. And so she definitely had to help my mom out; my dad was on the road when were little a lot and trying to make a living; he was in a band at the time. And I do remember Rosanna cleaning my ears and saying...

ROSANNA: Talking about the "cleaning your ear" thing?

PATRICIA: "Oh, there’s some sweet potatoes in there." And I remember her teaching me dances; really cute little dances to Mr. Big Stuff and..."

ROSANNA: Bumping - The Bump. Did I teach you The Bump?

PATRICIA: Uh huh, The Bump and we would listen to her records, like the Jackson Five. And she was my big sister; she’s always been my big sister and taught me a lot of stuff about the world.

ROSANNA: Oh, I remember Patricia came to the set of, was it... when did you come and you stayed with me in New York? I guess I was doing...

PATRICIA: You were doing Desperately Seeking Susan.

ROSANNA: I was doing Desperately Seeking Susan and you had a punk haircut, like a shaved head on one side and black...

PATRICIA: Yeah.

ROSANNA: Patricia said she wanted to be an actress and I thought that was so exciting, she was going to be an actress.

Patricia on being a punker:

"I was a punker but I always was soft-spoken, I mean, even when I had my Mohawk, instead of spiking it up I would braid it back with ribbons. I’ve always been interested in this visual that’s different and an artistic exploration but it’s always been tempered with a very old-fashioned notion of things, I guess. But Rosanna was the first person I ever told I wanted to be an actress, which shows how safe I felt with her. And she said, "Really? Okay, well there’s always room for another rose in the garden." And she’s the one who paid for my acting classes."